Why did we do this research?
The overall goal of this research was to leverage genomic information to identify individuals with high genetic risk for type two diabetes, assess their disease progression, accumulation of co-morbidities, and healthcare utilization, and characterize their beta-cell function, insulin resistance, and pharmacogenetic responses to type 2 diabetes therapies.
What were the aims of this research?
- Characterize the physiologic responses in individuals with extreme genetic risk for type 2 diabetes through a recall-by-genotype study.
- Characterize the pharmacological responses in individuals with extreme genetic risk for type 2 diabetes.
What were the outcomes?
- Pancreatic beta-cell function and insulin resistance measured with a mixed meal tolerance test
- Glycemic response to sulfonylurea as a drug challenge