Diabetes Research Center · MGH
“Our research program integrates human genetics, physiology, and clinical investigation to advance precision diabetes care. Through collaborative research spanning international consortia, biobanks linked to electronic health records, large-scale population cohorts, and deeply phenotyped clinical studies, we seek to understand the biological mechanisms underlying diabetes and translate these discoveries into clinically actionable strategies.” — Aaron Leong, MD, MSc
Human Studies
PROGRESS
PhaRmacogenetics Of the Glycemic RESponse to SGLT2 inhibitors
Investigating whether genetic variation informs SGLT2-inhibitor treatment response.
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CGM-A1c
CGM-A1c Genetics
Examining genetic contributions to discordance between HbA1c and continuous glucose monitoring measures.
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TARGET
Targeted Assessment through Recall by Genotype
Recall-by-genotype design for deep phenotyping across genetic risk groups.
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COVID
Cardiometabolic genetic variation & COVID-19 severity
Examining the genetics underlying diabetes-related complications in acute COVID-19.
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PATHS-T1D
Polygenic Assessment and Autoimmunity Testing for Health-System Screening of Type 1 Diabetes
Using polygenic risk scores to identify adults for early autoimmune diabetes screening.
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PATHS-T2D
Polygenic Assessment and Testing of Heterogeneity and Subtypes in Type 2 Diabetes
Investigating genetically defined subtypes of type 2 diabetes and their clinical relevance.
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Our Team









