Diabetes Research Center · MGH
The Leong Team bridges human genetics, deep phenotyping, and clinical care to change how diabetes is detected, classified, and treated.
Our Mission
“Our research program integrates human genetics, physiology, and clinical investigation to advance precision diabetes care. Through collaborative research spanning international consortia, biobanks linked to electronic health records, large-scale population cohorts, and deeply phenotyped clinical studies, we seek to understand the biological mechanisms underlying diabetes and translate these discoveries into clinically actionable strategies. Our mission is to develop and implement precision medicine approaches that improve the prevention, early detection, diagnosis, classification, and treatment of diabetes. Ultimately, we strive to improve health outcomes and enable more personalized, equitable care for people living with diabetes.” — Aaron Leong, MD, MSc
Human Studies
Four active studies, one shared goal.
PROGRESS
PhaRmacogenetics Of the Glycemic RESponse to SGLT2 inhibitors
Studying whether a patient’s genetic makeup should guide SGLT2-inhibitor prescribing.
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CGM-A1c
CGM-A1c Genetics
Pairing continuous glucose monitoring with genetics to explain HbA1c-glycemia mismatch.
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TARGET
Targeted Assessment through Recall by Genotype
Recalling participants for deep phenotyping based on their genetic risk profile.
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COVID
Diabetes genetics & COVID-19 severity
Examining the genetics underlying diabetes-related complications in acute COVID-19.
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Our Team









