Human Studies / PATHS-T2D
Precision Medicine · Recall-by-Genotype
Polygenic Assessment and Testing of Heterogeneity and Subtypes in Type 2 Diabetes
This study examines whether genetically defined subtypes of type 2 diabetes correspond to differences in physiology and treatment response, using a recall-by-genotype design to recruit participants across distinct genetic risk pathways.
Study Design
Aims & What Participation Involves
Aims
- Identify adults with high genetic risk for type 2 diabetes across distinct pathophysiological pathways.
- Characterize differences in glucose, insulin, and hormonal responses by genetic risk group.
What Participation Involves
- A baseline visit with a mixed-meal tolerance test to measure glucose, insulin, and hormone levels.
- For eligible participants: an at-home course of the study medication, orforglipron, followed by a second visit with a repeat test.